Stress is often called a silent killer, but the real culprit is oxidative stress within our cells, which is connected to disease, decline, and various health problems. The good news is that a high-quality glutathione supplement can make a difference. “Think of glutathione as your body’s natural defender,” says Nayan Patel, MD, an expert in advanced biochemistry and anti-aging science and founder of the wellness brand Auro. “It helps maintain cellular balance by shielding against daily stressors, revitalizing other antioxidants like vitamins C and E, and supporting the body’s built-in detox pathways, starting with the liver.”
Glutathione is a highly specialized tripeptide and the body’s most powerful antioxidant. “What makes glutathione unique is that it works inside the cell, where most oxidative stress actually occurs,” explains board-certified family medicine physician Heraa Chaudhry, MD. “Many antioxidants circulate in the bloodstream, but glutathione functions within cells to neutralize free radicals at their source.”
Vogue’s Favorite Glutathione Supplements:
– Best Overall: Pure Encapsulations Liposomal Glutathione – $68 at Amazon
– Best Liposomal: Codeage Liposomal Glutathione – $40 at Amazon
– Best for Antioxidant Support: Cymbiotika Liposomal Glutathione – $88 at Amazon
Our bodies produce glutathione naturally, and optimal levels can be supported through diet and lifestyle. “Sulfur-rich foods like broccoli, Brussels sprouts, garlic, and onions, along with adequate protein, regular exercise, and quality sleep, are essential for maintaining healthy glutathione levels,” says Dr. Chaudhry. However, nearly every aspect of modern life can deplete our glutathione reserves. “Aging, chronic stress, environmental exposure, poor sleep, and illness can all lower levels over time,” notes Dr. Patel. “Since oxidative stress is linked to almost every known disease, glutathione acts as the body’s primary natural protector, helping to maintain cellular balance.”
If you’re curious about this remarkable antioxidant, we consulted leading experts on the latest innovations, key ingredients to look for, and how to choose the best glutathione supplements available.
In This Story:
– What is glutathione?
– The Benefits of Glutathione
– What is the best form of taking glutathione?
– Is it better to take NAD or glutathione?
– How We Tested
– Meet the Experts
Best Glutathione Supplement Overall: Pure Encapsulations Liposomal Glutathione
Pure Encapsulations Liposomal Glutathione – $68 at Amazon
Why We Love It: Many professionals trust Pure Encapsulations for their premium quality, transparency, and effectiveness. This formula features a liposomal delivery system—a 125 mg phospholipid complex—that protects the glutathione from breaking down during digestion. “When choosing an effective glutathione supplement, look for transparency in formulation, clear dosing, and a delivery system designed to enhance absorption within cells,” advises Dr. Patel. “Glutathione is sensitive to degradation, so opt for a formula that prioritizes stability and protection from oxidation.” It also contains a clinically studied form of glutathione called Setria L-Glutathione, known for its purity, quality, and strong results. Pure Encapsulations goes a step further in transparency: while they list their proprietary complex BioGlute on the label, they clearly detail its contents—250mg of Setria L-glutathione and 125mg of a phospholipid complex.
Key Ingredients: Setria glutathione, phospholipid complex
Dose: 1 softgel
Form: Softgel
Size: 30 softgels
Best Glutathione Supplement for Antioxidant Support: Cymbiotika Liposomal Glutathione
Cymbiotika Liposomal Glutathione – $88 at Amazon
Why We Love It: One gel sachet per day provides a dose of reduced glutathione in a pleasant citrus-vanilla flavor, making it easy and enjoyable to take regularly. It’s ideal for busy days when you…Whether you’re on the go or packing for a trip, this squeezable gel is easy to take along. Dr. Chaudhry notes, “To get the most from glutathione, it’s about smart formulation, consistent use, and combining it with healthy habits like good nutrition, hydration, and quality sleep.” This gel also includes CoQ10, PQQ, and vitamin B12 for extra antioxidant and cellular support.
Key Ingredients: Reduced glutathione, PQQ, vitamin B12
Dose: 1 packet
Form: Gel
Size: 26 packets
Best Reduced Glutathione Supplement: BodyBio Liposomal Glutathione
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BodyBio Liposomal Glutathione
$71 | AMAZON
Why We Love It: Glutathione exists in cells in two forms: active (GSH) and inactive (GSSG). Dr. Patel explains, “GSH is the active antioxidant needed to fight free radicals and protect against toxins.” Research shows oral supplements can boost GSH levels, supporting immune function and reducing oxidative stress. These capsules use reduced glutathione in a liposomal form for better absorption and are made in a cGMP-certified facility with third-party testing.
Key Ingredients: Reduced glutathione, sunflower-derived phospholipids
Dose: 1 capsule
Form: Capsule
Size: 60 capsules
Best Liposomal Glutathione Supplement: Codeage Liposomal Glutathione
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Codeage Liposomal Glutathione
$40 | AMAZON
Why We Love It: Liposomes protect glutathione from stomach acid, helping it reach the intestines intact for better absorption. Dr. Chaudhry says, “Liposomal glutathione often has higher bioavailability due to its fat-based delivery.” Each serving provides 500mg of clinically-tested Setria L-glutathione in a powder capsule with a sunflower-derived liposomal complex. It’s vegan, non-GMO, and free from dairy, soy, and gluten.
Key Ingredients: Setria L-glutathione
Dose: 2 capsules
Form: Capsule
Size: 60 capsules
Best Glutathione Supplement with Milk Thistle: NOW Foods Glutathione
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NOW Foods Solutions Glutathione 500 mg
$24 $14 (42% off) | AMAZON
Why We Love It: This affordable, high-quality supplement is widely available and includes milk thistle extract, which can naturally boost glutathione levels by 35-50% by supporting liver health. Dr. Patel adds, “Healthy glutathione levels help keep cells, especially in the liver and nervous system, working at their best.” It also contains alpha lipoic acid.
Key Ingredients: Glutathione, milk thistle extract, alpha lipoic acid
Dose: 1 capsule
Form: Capsule
Size: 30 capsules
Best Liquid Glutathione Supplement: Quicksilver Scientific Liposomal Glutathione
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Quicksilver Scientific Liposomal Glutathione
$45 | AMAZON
Why We Love It: Available in refreshing lemon mint or cacao mint flavors, this liquid is perfect for those who prefer not to swallow pills. Dr. Chaudhry points out that liposomal forms improve stability and absorption. The formula uses nano liposomes (under 100nm) for even better uptake by the body.Dr. Patel notes that oral glutathione must survive digestion, which can affect its effectiveness, making the delivery method an important consideration in longevity discussions. For the liquid form, the recommended daily dose is two pumps taken by mouth. Hold the liquid under your tongue for 30 to 90 seconds before swallowing. This sublingual method may allow for faster absorption through the mouth’s tissues, bypassing the digestive system.
Key Ingredients: Opitac glutathione, phosphatidylcholine
Dose: 1 mL (2 pumps)
Form: Liquid
Size: 1.7 oz
Best Low Dose Glutathione Supplement: Renue by Science Lipo Glutathione
Renue by Science Lipo Glutathione – $52 (Amazon)
Why We Love It: Consistency is key with glutathione supplementation. These liposomal vegetarian capsules provide a low 130mg dose, ideal for beginners looking to support their glutathione levels. Most clinical studies show benefits with 250–500 mg daily. Dr. Patel advises newcomers to start with a low dose and increase gradually. “People have different levels of oxidative stress and detox capacity, so starting conservatively lets the body adjust,” he says. “Consistency is more important than a high dose at the beginning.”
Key Ingredients: Glutathione, sunflower lecithin
Dose: 1 capsule
Form: Capsule
Size: 90 capsules
Everything You Need to Know
What is glutathione?
Glutathione is a natural compound made from three amino acids: glutamine, cysteine, and glycine. “It’s often called the body’s ‘master antioxidant’ because it plays a central role in protecting cells from oxidative stress and supporting overall cellular health,” says Chaudhry.
The Benefits of Glutathione
Cellular Protection
Glutathione is essential for protecting your cells and mitochondria. “It helps the body manage everyday wear and tear,” says Chaudhry. “It neutralizes free radicals and supports healthy cell function.” By guarding against oxidative damage, glutathione is also vital in preventing chronic diseases. “Research continues to explore glutathione’s role in oxidative stress and cellular health,” adds Dr. Patel.
Detox Support
Glutathione aids the liver in detoxification, neutralizing harmful toxins and helping protect the liver from disease. “It’s central to the liver’s natural detox processes, helping the body eliminate waste,” says Dr. Chaudhry. “This combination of cellular protection and detox support is what makes it unique.”
Strengthens Immune Function
By boosting the activity of white blood cells that fight bacteria and viruses, glutathione can enhance the body’s immune defenses.
Metabolism Support
“Some studies on oral glutathione in people with metabolic conditions have shown reduced oxidative stress markers and modest improvements in metabolic measures over time,” says Dr. Patel. “Other research is looking at how it may affect immune cell activity and inflammation.”
Healthy Skin
According to Patel, glutathione is gaining popularity in longevity and aesthetic medicine for its potential to promote radiant skin and long-term cellular health. As a powerful antioxidant, it helps fight free radicals and oxidative damage in the skin. “It’s often linked to brighter, more even skin in wellness settings due to its effect on melanin pathways,” says Dr. Chaudhry.
What is the best form of taking glutathione?
Glutathione comes in many forms, including liquids, tablets, injections, IVs, and topical products. The best…The best form of glutathione depends on your goals and the delivery method. Dr. Chaudhry notes that while oral supplements are convenient, absorption can be inconsistent because they break down in the digestive system. In clinical settings, intravenous (IV) administration bypasses digestion, delivering glutathione directly into the bloodstream for more predictable absorption.
Dr. Patel points out that IV treatments can be effective short-term but may cause sharp, rapid spikes in blood levels that fade quickly. To address this, he developed a patented topical system that carries reduced glutathione through the skin and into circulation, which is used in his Auro Wellness products. He emphasizes that although research on glutathione is promising, it is still evolving, so it should be used thoughtfully under medical supervision.
Is it better to take NAD or glutathione?
NAD and glutathione play different but equally vital roles in the body. According to Dr. Patel, NAD is crucial for cellular energy and metabolism, while glutathione is the body’s main antioxidant and key for detoxification. Rather than choosing one, they work best together. Dr. Patel adds that many longevity experts consider supporting glutathione the foundational first step—helping the body manage oxidative stress and maintain cellular balance—before adding NAD to optimize energy and performance.
How We Tested
When testing and reviewing products, we take a holistic, science-backed approach, especially with supplements like glutathione. Our process starts by consulting healthcare professionals and longevity experts for insights into the most effective, evidence-based options. We combine their clinical expertise with rigorous product testing and editorial standards to create trusted, well-researched recommendations.
Meet The Experts
Dr. Nayan Patel is an expert in advanced biochemistry and anti-aging science, and the founder of Auro Wellness, a skincare company focused on antioxidants.
Dr. Heraa Chaudhry is a board-certified family medicine physician with over a decade of experience, specializing in preventative medicine, women’s health, and integrative wellness. She also serves as the medical director at Dripology NYC, a luxury IV therapy brand in New York.
Frequently Asked Questions
Frequently Asked Questions About Top Glutathione Supplements
Basics Definitions
Q What is glutathione and why is it important
A Glutathione is a powerful antioxidant naturally produced by your body Its often called the master antioxidant because it helps protect cells from damage supports the immune system and aids in detoxification
Q Why would I take a glutathione supplement if my body makes it
A Factors like aging chronic stress poor diet illness and environmental toxins can deplete your bodys natural glutathione levels Supplements are used to help restore optimal levels for better health and antioxidant support
Q What are the main forms of glutathione supplements
A The three most common forms are reduced glutathione liposomal glutathione and acetylated glutathione
Benefits Uses
Q What are the main benefits of taking a glutathione supplement
A Commonly cited benefits include enhanced skin brightening stronger immune function increased energy support for liver detoxification and reduced oxidative stress linked to aging and chronic conditions
Q Can glutathione really improve skin tone and lighten dark spots
A Yes this is one of its most popular uses Glutathione can inhibit melanin production which may lead to a more even skin tone and reduced appearance of dark spots over time Consistency is key
Q Do experts recommend glutathione for anything beyond skin and detox
A Yes Some experts highlight its role in supporting respiratory health reducing inflammation improving insulin sensitivity and potentially supporting brain health though more research is ongoing in these areas
Choosing a Supplement
Q What should I look for when choosing a toprated glutathione supplement
A Experts often recommend looking for reputable brands that use highquality absorbable forms have thirdparty testing for purity and provide clear dosage information
Q Is there a best type of glutathione for absorption
A Liposomal glutathione and acetylated glutathione are generally considered superior for absorption compared to standard reduced glutathione pills as they are better protected from breakdown in the digestive system