NAD+ (often called the fountain of youth in a bottle) is one of the biggest wellness trends today. Available in various forms—like IVs, injections, nasal sprays, and supplements—it’s used to tackle issues ranging from muscle loss and brain fog to aging skin and low energy.
Dr. Amanda Kahn, a board-certified internist and longevity expert, explains that nicotinamide adenine dinucleotide (NAD+) plays a key role in nearly every major cellular function. “It helps cells produce energy (ATP), protects against oxidative stress, aids in DNA repair, boosts collagen and elastin for youthful skin, supports brain and immune function, and maintains healthy blood flow for proper nutrient delivery,” she says. “Crucially, NAD+ also activates sirtuins, proteins that regulate inflammation and repair—both vital for longevity.”
### Vogue’s Top NAD+ Supplements:
– Best Overall: Tru Niagen Age Better NAD+ Supplement ($49)
– Best Vegan: Pure Encapsulations NR Longevity Supplement ($60)
– Best for Performance: Thorne NiaCel 400 Supplement ($70)
– Best with Polyphenols: Elysium Basis NAD+ Supplement ($60)
– Best NADH NAD+ Supplement: ProHealth Longevity NADH Pro Supplement ($39)
– Best with Resveratrol: Omre Nicotinamide Riboside + Resveratrol NAD Supplement ($60)
– Best Liposomal: Rho Nutrition Liposomal NAD+ Supplement ($56)
– Best Powder: Timebeam Beauty Bounce Mode Healthy Pixie Supplement ($49)
However, NAD+ molecules are too large to enter cells directly, raising questions about their effectiveness. That’s where NAD+ boosters come in. “Most supplements contain precursors like NR (nicotinamide riboside) or NMN (nicotinamide mononucleotide), which the body converts into NAD+,” says Dr. Lamees Hamdan, longevity expert and founder of Timebeam Beauty.
To help you choose the best NAD+ supplement, we consulted experts on what to look for and the key benefits.
### In This Article:
– What is NAD+?
– How does NAD+ work in the body?
– What are the benefits of taking NAD+?
– Are NAD+ supplements good for you?
– What to look for in NAD+ supplements
– Are there any risks?
– How much NAD+ should you take daily?
– Meet the Experts
### Best Overall NAD+ Supplement: Tru Niagen Age Better NAD+
Price: $49 (Amazon)
Why We Love It: Dr. Kahn recommends Tru Niagen for its well-researched, third-party-tested formula. It contains Niagen, a patented form of nicotinamide riboside (NR), which efficiently boosts NAD+ levels by penetrating cell membranes. Backed by over 35 peer-reviewed studies, Tru Niagen collaborates with top institutions like Mayo Clinic and Harvard, with 90% of its research independently conducted.
Type: NR
Dose: 2 capsules
### Best Vegan NAD+ Supplement: Pure Encapsulations NR Longevity
Price: $60 (Amazon)
Why We Love It: Another of Dr. Kahn’s picks, this supplement also uses the patented Niagen NR complex. Early studies suggest NR is safe and effective for raising NAD+ levels, supporting cell, heart, and muscle health. It’s hypoallergenic, non-GMO, gluten-free, and vegan-friendly, with added broccoli sprout extract.Here’s a more natural and fluent rewrite of your text:
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### Best NAD+ Supplement for Performance: Thorne NiaCel 400
Type: Nicotinamide riboside chloride
Dose: 1 capsule
Price: $64 (originally $70) on Amazon
Why we love it: Thorne is a trusted name in supplements, and their NiaCel 400 uses a unique form of NR (nicotinamide riboside) exclusive to their brand. It’s NSF Certified for Sport, meaning it’s free from banned substances—ideal for athletes. Just one capsule a day makes it easy to add to your routine.
### Best NAD+ Supplement with Polyphenols: Elysium Basis NAD+
Type: NR
Dose: 2 capsules
Price: $60 on Amazon
Why we love it: This supplement combines NAD+ precursor nicotinamide riboside with pterostilbene (PT), a potent plant polyphenol, to support cellular energy and combat daily stressors like pollution, poor diet, and aging. Plus, Elysium offers a 30-day money-back guarantee.
### Best NADH NAD+ Supplement: ProHealth Longevity NADH Pro
Type: NADH
Dose: 1 lozenge
Price: $37 (originally $39) on Amazon
Why we love it: These lemon-flavored lozenges dissolve under the tongue, delivering NADH—a form of NAD+ that may help with energy, focus, and even chronic fatigue. Early research suggests promising benefits, with more studies underway.
### Best NAD+ Supplement with Resveratrol: Omre Nicotinamide Riboside + Resveratrol
Type: NR
Dose: 2 capsules
Price: $60 on Amazon
Why we love it: This supplement boosts NAD+ production while adding resveratrol, a powerful antioxidant found in grapes. It’s free from fillers, artificial additives, and preservatives—making it a clean, effective choice.
### Best Sublingual NAD+ Supplement: Renue by Science Nicotinamide Riboside Powder
Type: NR
Dose: 2 scoops
Price: $79 (originally $109) on Amazon
Why we love it: Made in a GMP-certified facility and third-party tested, this citrus-flavored powder can be taken under the tongue or mixed into drinks. Ideal for those who prefer powders over pills.
### Best Liposomal NAD+ Supplement: Rho Nutrition Liposomal NAD+
Type: Liposomal NAD+
Dose: Liquid form
Price: $56 on Amazon
Why we love it: A convenient alternative to IV therapy, this lemon-flavored liquid is vegan, sugar-free, keto-friendly, and non-GMO—offering an easy way to boost NAD+ levels.
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Best Powder NAD+ Supplement: Timebeam Beauty Bounce Mode Healthy Pixie
Price: $49
Why We Love It:
While NAD+ is the star ingredient, it doesn’t work alone. This powder combines NAD+ with supporting nutrients like vitamin C, ribose, and rhodiola to enhance its effectiveness and absorption. The formula also includes a patented NAD+ booster called RiaGev-WS, which outperforms NMN and NR. Unlike other precursors, RiaGev-WS directly increases NAD+ levels while also boosting ATP and glutathione—two key longevity molecules—and lowering cortisol. Since absorption is crucial, the fast-dissolving powder can be taken straight on the tongue or mixed into drinks for an easy daily boost.
Type: RiaGev-WS
Dose: 1 packet
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Best NMN NAD+ Supplement: Wonderfeel Youngr NMN
Price: $88
Why We Love It:
This supplement blends NMN with vitamin D, resveratrol, and hydroxytyrosol (a powerful olive-derived antioxidant), earning praise from longevity experts. Unlike direct NAD+, precursors like NMN and NR are more efficiently absorbed and converted into NAD+ in cells. Early research also suggests NMN may support cognitive function. Developed with input from leading scientists, including Harvard- and Yale-trained Dr. Andrew Salzman, the formula is backed by rigorous science.
Type: NMN
Dose: 2 capsules
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### Everything You Need to Know About NAD+
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme found in every cell, produced from vitamin B3 (niacin). It fuels mitochondria—the cell’s energy factories—keeping cells energized and functional. NAD+ also supports DNA repair, metabolism, immunity, and stress response while reducing “zombie cells” (senescent cells).
How does NAD+ work in the body?
NAD+ is made from dietary precursors like niacin (found in salmon, beef liver, and peanuts) and tryptophan (found in turkey, eggs, and oats). Though not directly present in food, these nutrients help boost NAD+ levels.
Think of NAD+ as your cells’ energy currency—it powers essential processes and repairs DNA damage. But modern stressors (poor diet, inflammation, aging) deplete NAD+. Research shows levels drop by up to 50% by age 40, sometimes starting as early as 30, contributing to fatigue and aging symptoms.
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