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In skincare, there’s an unspoken rule: active ingredients should deliver clear benefits. But the best peptide serums go beyond just one advantage. These formulas—powered by peptides, small chains of amino acids that help cells communicate—can offer multiple perks, like extra hydration, boosted collagen, and reduced pigmentation.
### Vogue’s Top Peptide Serums:
– Best Overall: Medik8 Liquid Peptides, $64
– Best Doctor-Formulated: Eighth Day Regenerative Serum, $325
– Best for Mature Skin: Charlotte Tilbury Magic Serum Crystal Elixir, $85
– Best for Acne-Prone Skin: Biba de Sousa The Plant Stem Cell Serum, $95
– Best for Oily Skin: Rhode Peptide Glazing Fluid, $30
– Best for Dry Skin: Biossance Squalane + Copper Peptide Serum, $68
– Best for Sensitive Skin: Youth to the People Triple Peptide Serum, $57
Not all peptides work the same. Dr. Carmen Castilla, a board-certified dermatologist, explains: “A peptide’s benefits depend on its molecular size and structure.” Some stimulate collagen, others protect existing collagen and elastin, and some even enhance how well other ingredients (like hyaluronic acid) work.
### What to Know About Peptide Serums:
– What They Are: Formulas packed with peptides for skin repair.
– Benefits: Hydration, firmer skin, reduced wrinkles, brighter tone.
– Who Should Use Them: Anyone looking to improve texture, elasticity, or signs of aging.
### Our Top Picks:
#### Best Overall: Medik8 Liquid Peptides
Why We Love It: This serum packs 10 peptides to firm and plump skin, plus hyaluronic acid for instant hydration. Results show in weeks, not months.
Best For: Mature or dry skin.
Key Ingredients: Multiple peptides, hyaluronic acid.
Size: 30ml
#### Best Doctor-Formulated: Eighth Day Regenerative Serum
Why We Love It: Uses a patented peptide-rich plasma (similar to PRP) with 24 peptides, growth factors, and neuropeptides to smooth lines and brighten skin.
Best For: Mature skin or those targeting discoloration.
Key Ingredients: Peptide-rich plasma, niacinamide, glycolic acid.
Size: 15ml, 30ml, 50ml
#### Best for Mature Skin: Charlotte Tilbury Magic Serum Crystal Elixir
Why We Love It: A celeb-favorite formula that hydrates while improving elasticity and radiance.
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This version keeps the original meaning while making it more conversational and easier to read. Let me know if you’d like any further refinements!This serum is a favorite among celebrity clients like Gisele Bündchen and Kate Moss, so it’s no surprise she worked with top scientists to develop this anti-aging formula. Powered by Replexium—a proprietary blend of two peptides—it targets proteins and collagen to smooth wrinkles and fine lines. It also includes polyglutamic acid (even more hydrating than hyaluronic acid) and vitamin C for repair and protection. Just note: it has a fragrance.
Best for: Mature skin or early signs of aging
Key Ingredients: Acetyl tetrapeptide-11, acetyl tetrapeptide-9, vitamin C, niacinamide, polyglutamic acid
Size: 8 ml, 30 ml, 100 ml
✅ Love It
✔️ Doesn’t pill under moisturizer or makeup
✔️ Softens and smoothes skin
❌ Leave It
✖️ Noticeable floral scent (may not suit everyone)
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### Best for Acne-Prone Skin: Biba de Sousa Los Angeles The Plant Stem Cell Serum
Price: $95 (available at Moda Operandi, Revolve, Amazon)
Why We Love It: Along with peptides (Matrixyl 3000 and palmitoyl tripeptide) for collagen support and hyaluronic acid, this serum features echinacea plant stem cells for protection against new lines. CoQ10, a potent antioxidant, adds extra defense. Plus, it’s non-comedogenic—ideal for aging skin without breakouts.
Best for: Oily or acne-prone skin
Key Ingredients: Tripeptide-38, palmitoyl tripeptide-5, hyaluronic acid, panthenol, echinacea plant stem cell
Size: 30 ml
✅ Love It
✔️ Absorbs quickly, no residue
✔️ No noticeable scent
❌ Leave It
✖️ Nothing major to note
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### Best for Oily Skin: Rhode Peptide Glazing Fluid
Price: $30
Why We Love It: Created by Hailey Bieber, this gel-serum delivers the “glazed donut” effect with peptides, niacinamide, and hyaluronic acid. Marula oil adds instant plumpness and a glossy finish—without greasiness.
Best for: Oily or combination skin
Key Ingredients: Acetyl hexapeptide-8, niacinamide, hyaluronic acid, marula oil
Size: 50 ml
✅ Love It
✔️ Dewy (not greasy) finish
✔️ Lightweight, pleasant texture
❌ Leave It
✖️ Pump can be finicky
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### Best for Dry Skin: Biossance Squalane + Hyaluronic Acid Copper Peptide Rapid Plumping Serum
Price: $68 (Sephora, Amazon)
Why We Love It: Copper peptides boost long-term collagen, while hyaluronic acid, polyglutamic acid, and squalane provide instant hydration and plumpness.
Best for: Dry or dehydrated skin
Key Ingredients: Copper tripeptide-1, tetrapeptide-30, palmitoyl hexapeptide-5, hyaluronic acid, polyglutamic acid, squalane
Size: 50 ml
✅ Love It
✔️ Immediate smoother, plumper skin
✔️ Lightweight, absorbs fast
❌ Leave It
✖️ Not a moisturizer replacement
✖️ May pill under makeup
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### Best for Sensitive Skin: Youth to the People Triple Peptide Hydrating + Firming Oasis Serum
Price: $57 (Sephora, Nordstrom, Amazon)
Why We Love It: This concentrated serum features three peptides to hydrate and firm, making it a great reset for stressed skin.
Best for: Sensitive skin
Key Ingredients: Peptide blend, hyaluronic acid, squalane
Size: 30 ml
✅ Love It
✔️ Soothes and strengthens
✔️ Light, fast-absorbing
❌ Leave It
✖️ None notedHere’s a more natural and fluent rewrite of the text while keeping the original meaning intact:
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### Best for Dry or Sensitive Skin
This serum contains peptides that boost your skin’s natural collagen production, helping to reduce the appearance of fine lines and wrinkles over time. It’s specially designed for dehydrated skin (which lacks water, unlike dry skin that lacks oil). To deeply hydrate, it delivers four types of hyaluronic acid, minerals from malachite, and cactus stem water—all working together to attract and lock in moisture without heavy silicones or overpowering fragrances.
Key Ingredients: Palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, palmitoyl tripeptide-28, hyaluronic acid, cactus stem extract, rambutan peel extract
Size: 30 ml
Love It
✔ Absorbs quickly without stickiness
✔ Fragrance-free
Leave It
✖ Pump can be tricky to use
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### Best for Dark Spots: RéVive Brightening Serum (Vitamin C + Niacinamide + Bio-Renewal Peptide)
This serum helps fade discoloration and even out skin tone with three key brightening ingredients: a stable form of vitamin C (tetrahexyldecyl ascorbate), niacinamide, and hyaluronic acid. These work together to reduce excess pigment and boost radiance. The formula also includes the brand’s signature Bio-Renewal Peptide, discovered by plastic surgeon Dr. Gregory Bays Brown while studying wound healing. This peptide mimics skin’s natural renewal process, promoting smoother, more supple skin.
Best for: Mature skin or anyone dealing with dullness and hyperpigmentation
Key Ingredients: Hexapeptide-9, vitamin C, niacinamide, hyaluronic acid
Size: 30 ml
Love It
✔ Tackles multiple signs of aging
Leave It
✖ May be drying for some
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### Best for Lifting: Dr. Dennis Gross DermInfusions Fill + Repair Serum
Most topical products can’t lift sagging skin—that usually requires injectables. But this serum aims to change that with four peptides that stimulate collagen and elastin production to restore volume and firmness. Its unique delivery system also shrinks water molecules, allowing deeper penetration into the skin.
Best for: Mature or sun-damaged skin
Key Ingredients: Palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, oligopeptide-2, niacinamide, hyaluronic acid, ectoin
Size: 30 ml
Love It
✔ Leaves skin dewy
✔ Instantly plumps
Leave It
✖ Some may dislike the scent
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### Best for Deep Wrinkles: Peter Thomas Roth Peptide Skinjection Serum
This serum is designed to rival injectable treatments, packing nearly 30% peptides. It includes a powerful peptide complex (Matrixyl and Argireline) to boost collagen, plus a peptide that works like botulinum toxin to relax facial muscles and soften expression lines—helping both prevent and smooth wrinkles.
Best for: Anyone targeting wrinkles
Key Ingredients: Acetyl hexapeptide-8, pentapeptide-18, n-prolyl palmitoyl tripeptide-56 acetate, palmitoyl tripeptide-38, squalane, glycerin, phytosterols
Size: 30 ml
Love It
✔ Targets expression lines
✔ Fragrance-free
Leave It
✖ Refillable packaging is awkward
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### Best for Fine Lines: StriVectin Anti-Wrinkle Peptide Plump Serum
While many serums use multiple peptides, this one relies on a single, proprietary peptide to stimulate collagen, elastin, and other key proteins for firmer, smoother skin.
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This version keeps the original meaning while making the language more fluid and conversational. Let me know if you’d like any refinements!Here’s a natural, fluent rewrite of your text while preserving the original meaning:
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Hyaluronic Acid Boost
This serum replenishes hyaluronic acid—which naturally declines with age—to provide both instant and lasting plumping effects. It’s strong enough to soften even stubborn wrinkles, like forehead lines.
Best for: Early signs of aging
Key Ingredients: Pentapeptide-84, red algae extract, turmeric root extract
Size: 30 ml
Love It
✔ Lightweight, non-greasy feel
✔ Works fast and improves skin over time
Leave It
✘ Can pill under makeup
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Best for Volume: Doctor Babor Lifting Collagen Peptide Derma Filler Serum
Price: $179 (Amazon, Saks Fifth Avenue)
Why We Love It: Despite its name, this serum doesn’t contain actual collagen (which is too large to absorb into skin). Instead, it uses a peptide complex to boost the production of four different collagen types, leading to all-around firming and smoothing. It also includes lightweight hyaluronic acid for deep hydration and plumping.
Best for: Sagging skin or deep wrinkles
Key Ingredients: Collagen peptide complex, hyaluronic acid, ginseng extract, quinoa extract
Size: 30 ml
Love It
✔ Addresses stubborn aging concerns
Leave It
✘ Not the most hydrating formula
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Best for Daytime: Estée Lauder Futurist Peptide-Power Serum Primer
Price: $54 (Saks Fifth Avenue, Nordstrom, Dermstore)
Why We Love It: This hybrid serum-primer smooths skin while prepping it for makeup. Its gel texture glides on effortlessly, and key ingredients like hyaluronic acid, vitamin C, and peptides brighten and strengthen skin over time. Light-reflecting pearls give an instant glow.
Best for: Combination or oily skin, makeup prep
Key Ingredients: Acetyl hexapeptide-8, palmitoyl hexapeptide-12, hyaluronic acid, vitamin C, algae extract
Size: 30 ml
Love It
✔ Creates a flawless base for makeup
✔ Instantly brightens
Leave It
✘ The dropper can be tricky to use
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Best for Evening: Drunk Elephant Protini Powerpeptide Resurfacing Serum
Price: $82 (Sephora, Ulta Beauty, Amazon)
Why We Love It: This potent serum combines 10% lactic acid (a gentle exfoliant) with 11 peptides to smooth fine lines, shrink pores, and improve sun damage. Hyaluronic acid and green tea seed oil keep skin hydrated and calm.
Best for: Aging skin or hyperpigmentation
Key Ingredients: Multiple peptides, squalane, hyaluronic acid, lactic acid
Size: 30 ml
Love It
✔ Brightens and evens skin tone
✔ Fast results
Leave It
✘ May be too strong for very sensitive skin
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Best Affordable: The Ordinary Multi-Peptide + Copper Peptides 1% Serum
Price: $32 (Nordstrom, Sephora)
Why We Love It: A budget-friendly option with five peptides, including a copper peptide that boosts collagen and elastin production. Hyaluronic acid plumps skin, while the copper peptide also soothes inflammation.
Best for: Dry or sensitive skin
Key Ingredients: Copper tripeptide, hyaluronic acid
Size: 30 ml
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Best Multitasking: Lancer Triple Peptide Drops with Vitamin E + Niacinamide
Price: $125 (Dermstore, Saks Fifth Avenue), $80 (Amazon)
Why We Love It:
This serum combines peptides, antioxidants, and hyaluronic acid in one powerful formula—no need to choose between different treatments. It brightens, hydrates, and firms skin, thanks to its triple-peptide complex that boosts collagen production. The time-released peptides ensure long-lasting benefits.
Best for: Anyone looking for an all-in-one serum
Key Ingredients: Palmitoyl heptapeptide-14, heptapeptide-15 palmitate, tetrapeptide-72 amide, rice tetrapeptide, hyaluronic acid, vitamin E, niacinamide
Size: 30 ml
Love It:
– Dermatologist-formulated
– Time-released peptides work gradually
Leave It:
– The scent may take some getting used to
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Best Fast-Acting: SkinMedica TNS Advanced+ Serum
Price: $295 (Amazon, Bluemercury)
Why We Love It:
Dr. Castilla recommends this serum as one of the first truly effective peptide treatments. It blends growth factors and peptides to stimulate collagen, smoothing fine lines over time. The dual-chamber design keeps ingredients fresh—one side contains growth factors and peptides, while the other has botanical extracts for skin renewal. You may see results in as little as two weeks, and it’s gentle enough for daily use.
Best for: Aging skin
Key Ingredients: Dimer tripeptide-43, green microalgae, apple fruit extract, growth factors
Size: 30 ml
Love It:
– Combines peptides with growth factors
– Fragrance-free
Leave It:
– The dual-chamber pump can clog
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Best for Neck: Colorescience Pep Up Collagen Boost Face & Neck Treatment
Price: $179 (Amazon)
Why We Love It:
The neck and chest area also show signs of aging, and peptides offer a gentler alternative to retinol. Dr. Castilla likes this formula for its high peptide concentration, which enhances effectiveness. It’s lightweight, hydrating, and packed with antioxidants to protect delicate skin.
Best for: Targeting face and neck
Key Ingredients: Palmitoyl tripeptide-5, copper tripeptide-1, hyaluronic acid, and more
Size: 30 ml
Love It:
– Hydrates and smooths skin
– A little goes a long way
Leave It:
– Results take time
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### Everything You Need to Know
What is a peptide serum?
Peptide serums contain small molecules that naturally occur in skin. According to Dr. Jeanette Graf, peptides act as messengers, signaling skin cells to produce collagen, elastin, and other key components. Their small size allows them to work at a cellular level where other ingredients can’t.
What are the benefits?
Peptide serums can reduce wrinkles, strengthen the skin barrier, and calm inflammation.
Let me know if you’d like any further refinements!Peptides can help boost collagen and improve skin elasticity, according to Dr. Melanie Palm, a board-certified dermatologist in San Diego. However, their benefits vary depending on the type of peptide.
Dr. Carmen Castilla explains that signal peptides stimulate collagen and elastin production, while carrier peptides help deliver key ingredients to the skin to support collagen growth. Enzyme-inhibitor peptides, on the other hand, prevent collagen breakdown, which can lead to sagging and wrinkles.
Another popular type is neuropeptides, or “neurotransmitter inhibitor peptides,” which work similarly to neuromodulators (though on a smaller scale) by relaxing facial muscles to soften expression lines.
### Choosing a Peptide Serum
Dr. Jeanette Graf recommends formulas that combine peptides with hydrating ingredients like hyaluronic acid, ceramides, and glycerin to strengthen the skin barrier and keep skin plump and smooth.
Dr. Castilla notes that signal and carrier peptides—especially copper peptides—have the most research backing their anti-aging benefits. For plumper, smoother skin, she suggests opting for a signal peptide paired with hydrating ingredients like hyaluronic acid.
### Who Should Use Peptide Serums?
If you already use an antioxidant serum, retinoid, and sunscreen, adding a peptide serum can enhance your anti-aging routine. While peptides aren’t a complete solution on their own, they provide additional support.
Dr. Graf adds that consistent use helps stimulate collagen production, leading to firmer, brighter skin and slower signs of aging like fine lines.
Peptide serums are also a gentler alternative for those who can’t tolerate retinoids, as they offer some collagen-boosting benefits without irritation.
### Experts
– Dr. Carmen Castilla, board-certified dermatologist at New York Dermatology Group
– Dr. Melanie Palm, board-certified dermatologist at Art of Skin in San Diego
– Dr. Jeanette Graf, board-certified dermatologist and professor at Mount Sinai School of Medicine